This Mexican Meatloaf offers a delightful departure from the everyday, infusing classic comfort food with vibrant Southwestern flavors. Imagine a tender, moist loaf bursting with the warm spices of chili powder and cumin, all crowned with a zesty salsa topping that promises a satisfying meal. It’s the kind of dish that feels both familiar and exciting, perfect for gathering everyone around the table.
It’s a weeknight hero, requiring minimal fuss but delivering maximum flavor, making it ideal for busy schedules. This recipe is also wonderfully forgiving, and leftovers are fantastic for lunches, ensuring deliciousness throughout the week.
Why I Love This Recipe
This Mexican Meatloaf is a weeknight wonder!
- Quick Prep: Ready to bake in under 15 minutes.
- Flavor Packed: A fiesta of spices in every bite.
- Family Approved: A hearty meal that even picky eaters enjoy.
- Versatile: Perfect with simple sides or as part of a larger spread.
Mexican Meatloaf Ingredients
The magic of this Mexican Meatloaf lies in its simple yet impactful blend of familiar ingredients with a Southwestern flair. We’re taking a classic comfort food and giving it a delicious, zesty makeover that’s sure to become a new family favorite. It’s truly a culinary hug in a dish.
Here’s what you’ll need for this flavorful creation:
- Lean Ground Beef: This is the hearty foundation. It provides a satisfying texture and rich flavor for our Mexican Meatloaf.
- Crushed Corn Chips (or Breadcrumbs): These act as a binder. They help hold the loaf together. They also add a subtle crunch and authentic Mexican essence.
- Milk & Large Egg: These are essential binders. They contribute moisture and ensure the meatloaf holds its shape beautifully.
- Diced Onion & Green Bell Pepper: These aromatics soften as they bake. They infuse the meatloaf with sweet and savory undertones.
- Chopped Green Chilies: These are the secret to that gentle, smoky heat. It defines this special Mexican Meatloaf dish.
- Chili Powder, Ground Cumin, Garlic Powder, Salt, and Black Pepper: Our spice blend brings the signature warmth. It provides the depth of Mexican-inspired flavors.
- Salsa (for topping): This adds a bright, tangy finish. It creates a moist layer that complements all the savory meat.
- Shredded Monterey Jack or Cheddar Cheese (optional): For a gooey, cheesy crown. This takes our Mexican Meatloaf to the next level of deliciousness.
Substitutions and Tips
Feel free to swap the corn chips for regular breadcrumbs or panko if needed. If you don’t have fresh onion or bell pepper, 1/4 cup of onion powder and 1/4 cup of dried bell pepper flakes can be used. However, fresh offers a better texture. For an extra kick, use a spicier salsa. You could also add a pinch of cayenne pepper to the meat mixture. The cheese is entirely optional. It is highly recommended for that extra touch of indulgence. Exact quantities for all ingredients are available in the printable recipe card below. Happy cooking!
How to Make Mexican Meatloaf

Step 1: Prepare Your Oven and Pan
Preheat your oven. Set it to 350°F (175°C). Lightly grease a loaf pan. You can also line a baking sheet. Use parchment paper for easy cleanup.
Step 2: Combine the Meatloaf Mixture
In a large bowl, gently combine ingredients. Add ground beef and crushed corn chips. Pour in the milk and beaten egg. Add diced onion and bell pepper. Don’t forget the green chilies. Mix in chili powder, cumin, and garlic powder. Season with salt and pepper. Mix with your hands until just incorporated. Avoid overmixing. This keeps the Mexican Meatloaf tender.
Step 3: Shape and Top the Loaf
Form the meat mixture into a loaf shape. Place it in your prepared pan. Or, put it on the baking sheet. Spread the salsa evenly over the top. This salsa topping adds flavor.
Step 4: Bake the Mexican Meatloaf
Bake in the preheated oven. It needs 50 to 60 minutes total. Check for doneness with a thermometer. Insert it into the thickest part. It should reach 160°F (71°C). This ensures your Mexican Meatloaf is cooked through.
Step 5: Add Cheese (Optional) and Rest
If using cheese, sprinkle it over the salsa topping. Do this during the last 10 minutes of baking. Let it melt into a gooey crown. Once cooked, remove the Mexican Meatloaf from the oven. Let it rest for 5 to 10 minutes. This resting is key. It lets juices redistribute. This makes for a moist, well-formed meatloaf. It slices beautifully too.
H2: How to Store Mexican Meatloaf
Leftover Mexican Meatloaf is a treat later too. Store cooled portions in an airtight container. This keeps it fresh in the fridge for up to 4 days. For longer enjoyment, wrap the cooled loaf tightly. Use plastic wrap, then foil. Or, use a freezer-safe container. It freezes well for 2-3 months. Thaw it overnight in the fridge. Then, simply reheat and enjoy this delicious Mexican Meatloaf again.
Tips for Success
- Don’t overmix the meat. Gently combine ingredients. This keeps the Mexican Meatloaf tender.
- Use a meat thermometer for accuracy. The internal temperature should reach 160°F (71°C).
- Let the meatloaf rest after baking. This step is crucial for juiciness and structure.
- Crushed corn chips add authentic flavor and texture. Use them if possible!
- Adjust salsa spice level to your preference. Tailor it for your family.
Kitchen Tools You’ll Need
- A large mixing bowl is essential.
- You’ll need a loaf pan. A baking sheet works too.
- Parchment paper is optional. It helps with cleanup.
- Measure ingredients with cups and spoons.
- A meat thermometer is very helpful.
- Use a spatula or spoon for spreading.

Serving Suggestions
- Serve with Mexican rice. Add refried beans for a full meal.
- Corn on the cob is a great side. A fresh green salad works well too.
- Offer sour cream. Avocado slices are nice toppings.
- A cold Mexican lager pairs wonderfully. Agua fresca is also refreshing.
Mexican Meatloaf
- Prep Time: 15 minutes
- Cook Time: 50-60 minutes
- Total Time: 1 hour 5 minutes – 1 hour 15 minutes
- Yield: 6-8 servings
- Category: Main Course
- Method: Baking
- Cuisine: Mexican
- Diet: None
Description
A flavorful twist on classic meatloaf, this Mexican Meatloaf is seasoned with chili powder and cumin, and topped with salsa and optional cheese for a delicious and easy weeknight meal.
Ingredients
- 1.5 lbs lean ground beef
- 1/2 cup finely crushed corn chips or breadcrumbs
- 1/2 cup milk
- 1 large egg, lightly beaten
- 1/2 cup finely diced onion
- 1/4 cup finely diced green bell pepper
- 1 (4 oz) can chopped green chilies, drained
- 2 tbsp chili powder
- 1 tsp ground cumin
- 1/2 tsp garlic powder
- 1/2 tsp salt
- 1/4 tsp black pepper
- For the topping:
- 1/2 cup salsa (mild or medium)
- 1/4 cup shredded Monterey Jack or cheddar cheese (for topping, optional)
Instructions
- Preheat oven to 350°F (175°C). Lightly grease a loaf pan or line a baking sheet with parchment paper.
- In a large bowl, combine ground beef, crushed corn chips, milk, beaten egg, diced onion, diced green bell pepper, chopped green chilies, chili powder, cumin, garlic powder, salt, and black pepper.
- Mix thoroughly with your hands until just combined, but do not overmix.
- Form the meat mixture into a loaf shape and place it in the prepared loaf pan or on the baking sheet.
- Spread the salsa evenly over the top of the meatloaf.
- Bake for 50-60 minutes, or until the internal temperature reaches 160°F (71°C).
- During the last 10 minutes of baking, if using, sprinkle the shredded cheese over the top of the meatloaf and allow it to melt.
- Once cooked, remove from the oven and let the meatloaf rest for 5-10 minutes before slicing and serving. This helps the meatloaf hold its shape and retain juices.
Notes
- Using crushed corn chips instead of breadcrumbs adds a distinct Mexican flavor.
- Do not overmix the meat mixture, as this can result in a tough meatloaf.
- Resting the meatloaf after baking is crucial for a juicy and well-formed final product.









